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If you compute volumes by counting voxels in warped images, then you'll need to correct with the Jacobian determinant of the spatial transformation. If the transformation is just linear, then the correction is the Jacobian determinant of the applied affine transform. If doing things manually, then I would suggest working from the original images. It's much simpler. Best regards, -John -----Original Message----- From: SPM (Statistical Parametric Mapping) [mailto:[log in to unmask]] On Behalf Of Woo Suk, Tae Sent: Thursday, February 01, 2007 8:27 AM To: [log in to unmask] Subject: [SPM] MRI volumetry with spatially normalized images Dear SPMers. I am planning to measure the volumes of frontal and temporal gyri. And I think that each gyral volumes should be corrected by the volumes of whole brains or intracranial cavities. What I want to know is that the gyral volume measured with spatially normalized MRI have a same effect compared with the volume normalization by whole brain or intracranial cavities? And is it more appropriate measuring with affine registered MRI without warping? If anyone had experience in this kinds of measurement, any comment would be appreciated. Woo Suk, Tae Ph.D Seoul, Korea