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Hi everyone, Inherent in spatial normalization in SPM is the realigment of native images to account for subject motion by estimating the six-parameters used to minimize the difference between each scan and the reference scan. At this stage, SPM also provides the ability to write the 6 parameters in a file, which can then be entered later into the model specification level (fMRI-->design), in the design matrix. Would anyone recommend doing this? Or, is the realignment at the normalization stage sufficient? It seems to me that there is little sense in entering in the 6 parameters at two separate stages, if it is the same information that is being applied both times. I have heard it argued that this a more conservative way however. Opinions appreciated! Thanks Ben